This year is the 14th annual Puppy Bowl and the early odds are in at 5Dimes! Right now team Fluff is slated to win!
Teams were created in 2015 and according to Wikipedia:

In Puppy Bowl XII, Team Ruff won again by a score of 70-to-44.

In Puppy Bowl XIII, Team Fluff upset the heavily favored Team Ruff by a score of 93-38.

Current odds:
Team Fluff -140
Team Ruff +100

To place your wager visit 5Dimes!